PROJECT BACKGROUND
A custom 50K vascular disease SNP array has been developed in a collaborative effort between investigators from the Institute of Translational Medicine and Therapeutics (UPenn), the Broad Institute, SeattleSNPs, the CARE project, the DREAM project and the Wellcome Trust, Oxford. It aims to comprehensively assess the genetic diversity within pathways (approximately 2150 genes) underpinning primary and secondary vascular disease processes such as blood pressure, insulin resistance, metabolic disorders, dyslipidemia and inflammation. Individuals across a range of observational and case-control vascular disease cohorts will be genotyped with the first version of the array:
- the CARE consortia which includes the three Framingham cohorts, CARDIA, CHS, MESA, ARIC and the Jackson Heart Study
- DREAM and EpiDREAM studies
- NIDDK sponsored Chronic Renal Insufficency cohort (CRIC)
- a UPenn consortium of CVD studies including PennCATH
- a sundry collection of additional vascular disease cohorts.
Files available for download:
- Ancestry Informative Markers
- IBC v1 SNP details
- HAPMAP QC Samples
- IBC v2 SNP pre QC
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If you have any problems or concerns, please contact:
hareesh@mail.med.upenn.edubkeating@mail.med.upenn.edu .