Tilo Grosser, MD

Research Assistant Professor of
Pharmacology

Member, Institute for Translational Medicine and Therapeutics

Contact Information:
809 Biomedical Research Building II/III
421 Curie Boulevard
Philadelphia, PA 19104
Office: 215-573-7600
Fax: 215-573-9004

 

 

 

 

 

 

 

 

Peer-reviewed Papers

Email:

Education:
MD (Medicine), Heinrich-Heine University, Düsseldorf, Germany 1996

 

IF— Journal Impact Factor
SJR— SCImago Journal Rank

Lucitt MB, Price TS, Pizarro A, Wu W, Yocum AK, Seiler C, Pack MA, Blair IA, FitzGerald GA, Grosser T. Analysis of the zebrafish proteome during embryonic development. Molecular & Cellular Proteomics 7(5):981-94 (2008).

MCP’s May issue Cover Figure (download) 

Hahn CG, Banerjee A, Macdonald ML, Cho DS, Kamins J, Nie Z, Borgmann-Winter KE, Grosser T, Pizarro A, Ciccimaro E, Arnold SE, Wang HY, Blair IA. The post-synaptic density of human postmortem brain tissues: an experimental study paradigm for neuropsychiatric illnesses. PLoS One. 2009;4(4):e5251. Epub 2009 Apr 16. PMID: 19370153

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Marzoll A, Nagy N, Wördehoff L, Fries S, Lindner V, Grosser T, Fischer JW. Cyclooxygenase Inhibitors Repress Vascular Hyaluronan-Synthesis in Murine Atherosclerosis and Neointimal Thickening. J Cell Mol Med. 2009 Mar 17. [Epub ahead of print] PMID: 19320776 (IF: 5.114)

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Stampfuss JJ, Censarek P, Fischer JW, Kaber G, Rauch BH, Freidel K, Fischer U, Schulze-Osthoff K, Grosser T, Grandoch M, Schrör K, Weber AA.Complete downmodulation of P-selectin glycoprotein ligand in monocytes undergoing apoptosis. Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1375-8. (IF: 7.221; SJR: 1,270) PMID: 18451333

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Lucitt MB, Price TS, Pizarro A, Wu W, Yocum AK, Seiler C, Pack MA, Blair IA, FitzGerald GA, Grosser T. Analysis of the zebrafish proteome during embryonic development. Molecular & Cellular Proteomics 7(5):981-94 (2008). (IF: 9.620; SJR: 2.170). MCP’s May issue Cover Figure (download)

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Song WL, Wang M, Ricciotti E, Fries S, Yu Y, Grosser T, Reilly M, Lawson JA, FitzGerald GA. Tetranor PGDM: An abundant urinary metabolite reflects biosynthesis of PGD2 in mice and humans. J Biol Chem 283(2):1179-88. (2008) (IF: 5.808; SJR: 1.896).

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Censarek P, Steger G, Paolini C, Hohlfeld T, Grosser T, Zimmermann N, Fleckenstein D, Schror K, Weber AA. Alternative splicing of platelet cyclooxygenase-2 mRNA in patients after coronary artery bypass grafting. Thrombosis and Haemostasis 98(6):1309-15 (2007). (IF: 2.803; SJR: 0.515).

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North TE, Goessling W, Walkley CR, Lengerke C, Kopani KR, Lord AM, Weber G,  Jang IH, Grosser T, FitzGerald GA, Daley GQ, Orkin SH, Zon LI. Prostaglandin E2 Regulates Vertebrate Hematopoietic Stem Cell Homeostasis, Nature, 447(7147):1007-11 (2007). (IF: 26.681; SJR: 6.203).

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Price TS, Lucitt MB, Wu W, Austin DJ, Pizarro A, Yocum AK, Blair IA, FitzGerald GA, Grosser T.
EBP: Protein identification using multiple tandem mass spectrometry datasets.
Mol Cell Proteomics. 6(3):527-36, (2007). (IF: 9.620; SJR: 2.170).

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Fries S*, Grosser T* *[Co-Firstauthors], Lawson J, DeMarco S, FitzGerald GA. Marked Interindividual Variability in the Response to Selective Inhibitors of Cyclooxygenase-2., Gastroenterology  Jan;130(1):55-64 (2006). (IF: 12.457; SJR: 1.644).

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Rudic RD, McNamara P, Reilly D, Grosser T, Curtis AM, Price T, Panda S, Hogenesch J, FitzGerald GA, Bioinformatic analysis of circadian gene oscillation in mouse aorta. Circulation;112(17):2716-24 (2005). (IF: 10.940; SJR: 1.993).

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Pini B*, Grosser T* *[Co-Firstauthors], Lawson J, Price TS, Pack M, FitzGerald GA. Zebrafish prostaglandin E2 synthases, Arteriosclerosis, Thrombosis, and Vascular Biology; 25(2):315-320 (2005). (IF: 7.053; SJR: 1.288).

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Grosser T, Yusuff  S, Cheskis E, Pack M, FitzGerald GA. Developmental expression of functional cyclooxygenases in zebrafish. Proc Natl Acad Sci (USA) 99 (12): 8418-23 (2002). (IF: 10.700; SJR: 3.732).

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Cheng Y, Austin S, Rocca B, Koller BH, Coffman, TM, Grosser T, Lawson JA, FitzGerald GA. Role of prostacyclin in the cardiovascular response to thromboxane A2. Science 296 (5567): 417-604 (2002).
(IF: 26.682;
SJR: 7.132).

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Ibe W, Bartels W, Lindemann S, Grosser T, Buerke M, Boissel JP, Meyer J, Darius H. Involvement of PKC and NF-kappaB in nitric oxide induced apoptosis in human coronary artery smooth muscle cells. Cell Physiol Biochem 11(5):231-40 (2001). (IF: 2.853; SJR: 0.397).

 

Lindemann S, Sharafi M, Spiecker M, Buerke M, Fisch A, Grosser T, Veit K, Gierer C, Ibe W, Meyer J, Darius H. NO reduces PMN adhesion to human vascular endothelial cells due to downregulation of ICAM-1 mRNA and surface expression. Thrombosis Research 97(3):113-23 (2000). (IF: 1.323; SJR: 0.248).

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Zacharowski K, Schneidmuller D, Ibe W, Grosser T, Buerke M, Meyer J, Darius H. Effects of local delivery of trapidil on neointima formation in a rabbit angioplasty model. British Journal of Pharmacology 129(3):566-72 (2000). (IF: 3.689; SJR: 0.932).

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Veit K, Boissel JP, Buerke M, Grosser T, Meyer J, Darius H. Highly efficient liposome-mediated gene transfer of inducible nitric oxide synthase in vivo and in vitro in vascular smooth muscle cells. Cardiovascular Research 43(3):808-22 (1999). (IF: 3.092; SJR: 0.155).

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Zucker T-P, Boenisch D, Hasse A, Grosser T, Weber A-A, Schror K. Tolerance development to antimitogenic actions of prostacyclin but not to prostaglandin E1 in coronary artery smooth muscle cells. Eur J Pharmacol 345, 213-220 (1997). (IF: 2.047).

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Grosser T, Zucker T-P, Weber A-A, Schulte K, Sachinids A, Vetter H, Schror K Thromboxane A2 induces cell signaling but requires platelet-derived growth factor to act as a mitogen. Eur J Pharmacol 319, 327-332 (1997). (IF: 2.047).

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Braun M, Grosser T, Schror K. Bioactivation of nitroglycerin in vascular smooth muscle cells is different from that in non-vascular tissue. Eur J Pharmacol 276, 239-245 (1995).

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Grosser T, Boenisch D, Zucker T-P, Schror K. Iloprost-induced inhibition of proliferation of coronary artery smooth muscle cells is abolished by homologous desensitization. Agents Actions 45, 85-91 (1995).

 

Zucker T-P, Grosser T, Morinelli T, Halushka PV, Sachinidis A, Vetter H, Schror K. Potentiation of PDGF-induced growth responses in coronary artery smooth muscle cells by thromboxane. Agents Actions 45, 53-58 (1995).